Mice have the ability to regenerate destroyed insulin-producing beta-cells. One of the aims of this research project is to examine how they do this.
Background
Beta-cells, which are part of the pancreas, are responsible for the regulation of blood sugar. They measure blood sugar constantly and pour out insulin if necessary. In type 1 diabetes patients, these beta-cells are completely or almost completely lost. The hope is that these beta-cells can be regenerated in adult diabetics.
This research project is based on an astonishing observation: After the destruction of more than 99 percent of all beta-cells, the mouse pancreas has the ability to regenerate up to ten percent of these cells. How does this happen? Researchers noticed that other cells of the pancreas, so-called non beta-cells, can be reprogrammed to become new beta-cells. Are stem cells involved in this process? And how is this process regulated?
Aim
With the help of genetically modified mice, the researchers will examine which cells these beta-cells come from and which factors are involved in this process.
Significance
About 20,000 people suffer from type 1 diabetes in Switzerland. Even if this disease can be treated with insulin injections, new therapeutic options are important, particularly to avoid diabetes-associated complications (blindness, renal failure, gangrene). This project promises to deliver new insights into the renewal of beta-cells and therefore new treatments.
Original title: Regeneration of new insulin-producing beta-cells in adult pancreas: plasticity and reprogramming of adult pancreatic cells
Grant: CHF 517’599.-
Duration: 36 months
Project leader
- Prof. Pedro Herrera, Université de Genève, Faculté de Médecine